Carlton's '300 Club' is an esteemed grouping, consisting of only 6 players:
| Rank | Games Played | Player | First Game | Last Game |
| 1 | 375 | Craig Bradley | Round 1, 1986 | Round 19, 2002 |
| 2 | 356 | Bruce Doull | Round 5, 1969 | Grand Final, 1986 |
| 3 | 342 | Kade Simpson | Round 11, 2003 | Round 18, 2020 |
| 4 | 328 | John Nicholls | Round 1, 1957 | Round 17, 1974 |
| 5 | 312 | Stephen Silvagni | Round 7, 1985 | Semi Final, 2001 |
| 6 | 300 | Marc Murphy | Round 1, 2006 | Round 22, 2021 |