| Round | Opponent | Venue | Date | Home / Away | Result |
| 1 | Richmond | Princes Park | Saturday 8 May | Home | Won by 44 points |
| 2 | Footscray | Western Oval | Saturday Date Month | Away | Won by 20 points |
| 3 | BYE | NA | Saturday 22 May | NA | NA |
| 4 | Collingwood | Princes Park | Saturday 29 May | Home | Lost by 27 points |
| 5 | St Kilda | Toorak Park | Saturday 5 June | Away | Lost by 12 points |
| 6 | Essendon | Princes Park | Saturday 12 June | Home | Lost by 6 points |
| 7 | Melbourne | Punt Road Oval | Saturday 19 June | Away | Lost by 5 points |
| 8 | Fitzroy | Princes Park | Saturday 26 June | Home | Won by 39 points |
| 9 | Sth Melbourne | Princes Park | Saturday 3 July | Away * | Won by 30 points |
| 10 | Hawthorn | Princes Park | Saturday 10 July | Home | Won by 25 points |
| 11 | Nth Melbourne | Arden Street | Saturday 17 July | Away | Lost by 4 points |
| 12 | Collingwood | Victoria Park | Saturday 31 July | Away | Won by 104 points |
| 13 | Hawthorn | Princes Park | Saturday 7 August | Home | Won by 22 points |
| 14 | Essendon | Windy Hill | Saturday 14 August | Away | Won by 3 points |
| 15 | Nth Melbourne | Princes Park | Saturday 21 August | Home | Won by 66 points |
| 16 | Fitzroy | Brunswick Street Oval | Saturday 28 August | Away | Lost by 15 points |
| SF | Fitzroy | Princes Park | Saturday 4 September | Away | Lost by 41 points |
Note: Round 9 game played at Princes Park was an away game for the Blues due to ground availability during World War II.